ukurasa_bango

Njia za kawaida za ulinzi wa amino

Njia za kawaida za ulinzi wa amino

1. Cbz
Benzyloxycarbonyl (Cbz) Amino Inayolindwa
Uzuiaji wa N-benzyloxycarbonyl (Cbz)
Vitendanishi vinavyotumiwa kawaida - CbzCl

2. Alloc
Kikundi cha amino kilicholindwa cha Allyloxycarbonyl (Alloc).

3. Trifluoroacetyl
Kikundi cha amino kilicholindwa cha Trifluoroacetyl

4. Benzyl
p-methoxybenzyl (PMB) kikundi cha amino kinacholindwa
Kikundi cha amino kilicholindwa cha 2,4-dimethoxybenzyl
Benzyl inalinda amino
Ulinzi wa kikundi cha amino kinacholindwa na benzyl
Upunguzaji wa N-Bn kwa njia ya kloroformate

5. Pht (phthaloyl)
Phthaloyl (Pht) ililinda vikundi vya amino
Ulinzi wa kikundi cha amino kinacholindwa na phthaloyl

6. Benzenesulfonyl
Kikundi cha amino kilicholindwa cha nitrobenzenesulfonyl
p-toluenesulfonyl (Tos) ulinzi wa amino

7. Trt
Trityl inalinda amino
Ulinzi wa kikundi cha amino zinazolindwa na trityl

8. Boc
Kikundi cha amino kilicholindwa cha Tert-butoxycarbonyl
Uzuiaji wa N-tert-butoxycarbonyl
Oxalyl Chloride De-Boc

9. Fmoc
Wat methoxycarbonyl iliyolindwa na kikundi cha amino
Vitendanishi vinavyotumiwa kawaida - Fmoc-Cl

10. SEM
SEM ililinda amino

11. Wengine
Acetamide iliyolindwa na kikundi cha amino
Majibu ya usanisi ya Clauson-Kaas pyrrole (majibu haya yanaweza kutumika kama njia ya kulinda vikundi vya amino, inaweza kuchukua nafasi ya ulinzi wa Boc mara mbili, na ni thabiti zaidi)
Vitendanishi vinavyotumiwa kawaida - benzyl (chloromethyl) ether
Vitendanishi vinavyotumika sana - (chloromethyl) methyl etha [MOMCl]
Ulinzi wa Carbamate


Muda wa kutuma: Sep-07-2023